Rapamycin rescues loss-of-function in blood-brain barrier-interacting regulatory T cells
P. Baeten, I. Hamad, C. Hoeks, M. Hiltensperger, B. Van Wijmeersch, V. Popescu, L. Aly, V. Somers, T. Korn, M. Kleinewietfeld, N. Hellings, B. Broux
This study shows that inflamed blood-brain barrier (BBB) impairs regulatory T cell (Treg) function, but rapamycin restores their suppressive ability.
bioRxiv · Oct 21, 2022Immunology