Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability in cancer
Z. Li, L. Ferguson, K. K. Deol, M. A. Roberts, L. Magtanong, M. C. Bassik, S. J. Dixon, N. Ingolia, J. Olzmann
The paper identifies LRP8 as a ferroptosis resistance factor in cancer, showing that its loss causes ribosome stalling during GPX4 translation, exposing a vulnerability in cancer cells.
bioRxiv · Apr 11, 2022Cancer Biology