Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies
C. Scheepers, P. Kgagudi, N. Mzindle, E. S. Gray, T. Moyo-Gwete, B. E. Lambson, B. Oosthuysen, B. Mabvakure, N. J. Garrett, S. S. A. Karim, L. Morris, P. L. Moore
This study compares three HIV MPER-targeting antibodies, showing that CAP206-CH12's dependence on a variable residue limits its neutralization breadth, unlike the conserved residue reliance of 4E10 and VRC42.01.
bioRxiv · Mar 18, 2022Immunology