C. Scheepers

nELISA: A high-throughput, high-plex platform enables quantitative profiling of the inflammatory secretome

nELISA enables high-throughput, high-plex protein profiling of the inflammatory secretome, revealing 447 significant cytokine responses across multiple donors and conditions.

Enhanced neutralization potency of an identical HIV neutralizing antibody expressed as different isotypes is achieved through genetically distinct mechanisms

This study investigates how different isotypes of the same HIV-neutralizing antibody achieve enhanced neutralization potency through distinct mechanisms involving hinge and CH1 regions.

Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies

This study compares three HIV MPER-targeting antibodies, showing that CAP206-CH12's dependence on a variable residue limits its neutralization breadth, unlike the conserved residue reliance of 4E10 and VRC42.01.

Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function

The paper identifies 13 rare mutations in the Omicron S-gene that cluster in functionally important regions and likely impact Spike function, suggesting cooperative interactions that mitigate fitness costs.

Sequence and functional characterization of a public HIV-specific antibody clonotype

The paper characterizes a public HIV-specific antibody clonotype from three individuals, showing that antigen specificity is modulated by VH germline genes and that non-native heavy-light chain pairings maintain consistent antigen recognition.

Pupillary responses to affective words in bilinguals’ first versus second language

The paper measures pupillary responses to affective words in bilinguals' first and second languages, finding stronger arousal effects in the first language, supporting reduced emotional resonance in L2.