ImmunologybioRxiv
Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies
C. Scheepers, P. Kgagudi, N. Mzindle…·P. L. Moore
This study compares three HIV MPER-targeting antibodies, showing that CAP206-CH12's dependence on a variable residue limits its neutralization breadth, unlike the conserved residue reliance of 4E10 and VRC42.01.
DOI 10.1371/journal.ppat.1010450