Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tension
I. Aifuwa, J. M. Phillip, B. Kim, T. Luperchio, A. Jimenez, T. Perestrelo, S.-H. Lee, N. Longe, K. Reddy, T. Ha, D. Wirtz
This study shows senescent stroma reduces cancer cell nuclear tension via RhoA/ROCK/myosin II inhibition, leading to morphological changes linked to malignancy.
bioRxiv · Nov 17, 2021Cancer Biology