S.-H. Lee

Epigenetic Dynamics in Meniscus Cell Migration and its Zonal Dependency in Response to Inflammatory Conditions: Implications for Regeneration Strategies

This study investigates how epigenetic mechanisms regulate meniscus cell migration under inflammation, revealing zonal differences and potential therapeutic targets.

Determination of the absolute concentration of Rayleigh particles via scattering microscopy

This paper introduces iCAUNT, a method to measure the absolute concentration of nanoparticles smaller than one-tenth of the imaging light wavelength using scattering microscopy.

Structural and Biophysical Dynamics of Fungal Plasma Membrane Proteins and Implications for Echinocandin Action in Candida glabrata

This study investigates the structural and dynamic organization of plasma membrane proteins in Candida glabrata using cryo-ET and live cell imaging, revealing how echinocandin drugs affect their distribution and function.

Human hypothalamic neural stem cells transplantation ameliorates age-associated dysfunction through SNS/eNAMPT axis activation in aged mice

Transplanting human hypothalamic neural stem cells into aged mice improves metabolic, physical, and cognitive function via the SNS/eNAMPT axis.

Locomotion-dependent auditory gating to the parietal cortex guides multisensory decisions

The paper shows that locomotion in mice shifts sensory dominance from auditory to visual during conflicts by altering neural circuits in the parietal cortex.

Formation of a giant unilocular vacuole via macropinocytosis-like process confers anoikis resistance

The paper shows that disrupting the actin cytoskeleton leads to the formation of a giant unilocular vacuole, which confers anoikis resistance in cells losing matrix attachment.

Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling

This study shows that IPMK regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling, impacting immune responses and autoimmune disease models.

Genomic hypomethylation in cell-free DNA predicts responses to checkpoint blockade in lung and breast cancer

This study develops iMethyl, a method to estimate genomic hypomethylation from cell-free DNA to predict responses to immune checkpoint blockade in cancer patients.

The defined TLR3 agonist, Nexavant, exhibits anti-cancer efficacy and potentiates anti-PD-1 antibody therapy by enhancing immune cell infiltration.

This paper evaluates Nexavant, a TLR3 agonist, showing enhanced anti-cancer effects and synergy with anti-PD-1 therapy through immune cell infiltration.

Robust prediction of patient outcomes with immune checkpoint blockade therapy for cancer using common clinical, pathologic, and genomic features

This study develops a logistic regression model to predict immune checkpoint blockade response and survival in cancer patients using common clinical and genomic features.

Spatial correspondence in relative space regulates serial dependence

The paper tests how serial dependence is influenced by spatial correspondence in relative versus absolute space, finding stronger effects from relative space.

CRISPR/Cas9 screen identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer

The paper identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer through CRISPR/Cas9 screening and shows targeting COX-2 enhances immune checkpoint blockade efficacy.

Static and dynamic analysis of in-vivo imaging for early-detection of lymphedema via near-infrared fluorescence indocyanine green lymphangiography

This study uses NIRF-ICG lymphangiography to analyze static and dynamic lymphatic function in lymphedema models, showing that dynamic analysis detects contractile abnormalities more effectively than static analysis.

Anti-integrin αvβ6 autoantibodies are a novel predictive biomarker in ulcerative colitis

This study identifies anti-integrin αvβ6 autoantibodies as a predictive biomarker for ulcerative colitis, showing they precede diagnosis by up to 10 years and correlate with adverse outcomes.

Cardiomyocyte alpha-1A adrenergic receptors mitigate post-infarct remodeling and mortality by constraining necroptosis

This study shows that cardiomyocyte alpha-1A adrenergic receptors reduce post-infarct mortality and remodeling by limiting necroptosis, with clinical evidence linking beta-blocker use to increased MI mortality.

Inhibiting 5-lipoxygenase prevents skeletal muscle atrophy by targeting organogenesis signaling and insulin-like growth factor-1

This study shows that inhibiting 5-lipoxygenase with malotilate prevents skeletal muscle atrophy by enhancing organogenesis signaling and insulin-like growth factor-1 expression.

Adolescent parvalbumin expression in the left orbitofrontal cortex shapes sociability in female mice

This study shows that adolescent social isolation in female mice leads to increased sociability, reduced parvalbumin expression, and decreased social sniffing activity in the left orbitofrontal cortex, highlighting the role of PV+ inhibitory circuits in shaping female social behavior.

Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tension

This study shows senescent stroma reduces cancer cell nuclear tension via RhoA/ROCK/myosin II inhibition, leading to morphological changes linked to malignancy.

Intestinal epithelial IPMK protects mice from experimental colitis via governing colonic tuft cell development

This study shows that IPMK in intestinal epithelial cells protects against colitis by regulating tuft cell development and cholinergic signaling.

A small molecule drug screening identifies colistin sulfate as an enhancer of Natural Killer cell cytotoxicity.

The paper screens FDA-approved drugs to find a small molecule that enhances NK cell cytotoxicity against cancer cells.

Phosphoproteomic analysis of chondrocytes after short-term exposure to inorganic polyphosphate

This study uses phosphoproteomic analysis to identify key proteins involved in chondrocyte metabolism after exposure to inorganic polyphosphate.

Effects of Platycodon grandiflorum on Gut Microbiota and Immune System of Immunosuppressed Mouse

This study investigates the effects of Platycodon grandiflorum diets on gut microbiota and immune system in immunosuppressed mice, finding increased microbial abundance and immune-related biomarker changes.

Novel Paju Apodemus Paramyxovirus 1 and 2, Harbored by Apodemus agrarius in The Republic of Korea

This study identifies two novel paramyxoviruses, PAPV-1 and PAPV-2, from Apodemus agrarius rodents in Korea, revealing distinct genome structures and zoonotic potential.

Transcriptional analysis of immune modulatory genes in melanoma treated with PD-1 blockade

The paper identifies key immune genes and develops a transcriptional deviance score to predict immune checkpoint inhibitor responses in melanoma patients.

Multiscale Characterization of Complex Binding Interactions of Cellulolytic Enzymes Highlights Limitations of Classical Approaches

This study uses single-molecule assays and simulations to show how CBM1 binding affects cellulase activity on different cellulose allomorphs, highlighting limitations of classical binding models.

Whole exome precision oncology targeting synthetic lethal vulnerabilities across the tumor transcriptome

This paper predicts patient response to cancer therapies using computationally derived genetic interactions across multiple tumor transcriptomics datasets.

Long-term functional culture and in vitro manipulation of adult mouse cardiomyocytes

This study develops methods to culture adult mouse cardiomyocytes long-term, maintaining their structure and function for in vitro experiments and genetic manipulations.

Dynamic healing and remodeling of mandibular ramus in segmental mobility and cortical overlap after intraoral vertical osteotomy

This study examines 3D morphological changes in the mandibular ramus after IVRO, showing dynamic remodeling and association with immediate postoperative overlap patterns.

Broad Dengue Neutralization in Mosquitoes Expressing an Engineered Antibody

This paper develops genetically engineered Aedes aegypti mosquitoes expressing an engineered antibody that broadly neutralizes all four DENV serotypes, significantly reducing viral transmission.

The Ras family members follow the blood progesterone level during formation and regression in bovine corpus luteum

The paper examines the relationship between Ras family members and blood progesterone levels during bovine corpus luteum formation and regression, finding correlations with angiogenesis and apoptosis.