Cancer BiologybioRxiv
Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tension
I. Aifuwa, J. M. Phillip, B. Kim…·D. Wirtz
This study shows senescent stroma reduces cancer cell nuclear tension via RhoA/ROCK/myosin II inhibition, leading to morphological changes linked to malignancy.
DOI 10.1093/pnasnexus/pgac270