Author

N. Mantis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:non-human primate· 1 Assay:protein structure· 1

Frequent Co-Authors

D. Ehrbar· 3 shared Y. Rong· 3 shared C. J. Roy· 1 shared C. R. Middaught· 1 shared D. J. Vance· 1 shared D. Kim· 1 shared D. Volkin· 1 shared D. Weis· 1 shared

Activity by Year

2018-2018 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

D. Ehrbar

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Humanized Monoclonal Antibody against the Enzymatic Subunit of Ricin Toxin Rescues Rhesus macaques from the Lethality of Aerosolized Ricin

C. J. Roy, D. Ehrbar, N. Bohorova, O. Bohorov, D. Kim, M. Pauley, K. Whaley, Y. Rong, F. J. Torres-Velez, E. Vitetta, P. J. Didier, L. Doyle-Meyers, L. Zeitlin, N. Mantis

This study shows that huPB10, a humanized monoclonal antibody, can rescue rhesus macaques from lethal ricin exposure when administered within four hours of aerosolized ricin exposure.

bioRxiv · Sep 6, 2018 · PreprintImmunology

Fine Specificity Epitope Analysis by HX-MS Identifies Contact Points on Ricin Toxin Recognized by Protective Monoclonal Antibodies

G. Van Slyke, S. K. Angalakurthi, R. T. Toth, D. J. Vance, Y. Rong, D. Ehrbar, Y. Shi, C. R. Middaught, D. Volkin, D. Weis, N. Mantis

This study identifies protective monoclonal antibodies against ricin by mapping their epitopes using HX-MS and shows that specific contact points on RTA correlate with in vivo protection.

bioRxiv · Jun 14, 2018Immunology

TRAIL (CD253) Sensitizes Human Airway Epithelial Cells to Toxin-Induced Cell Death

Y. Rong, J. Westfall, D. Ehrbar, T. LaRocca, N. Mantis

This study shows TRAIL sensitizes Calu-3 cells to ricin-induced apoptosis through extrinsic pathways, with significant upregulation of IL-6.

bioRxiv · May 15, 2018Immunology