D. J. Vance

Single-domain antibodies reveal unique borreliacidal epitopes on the Lyme disease vaccine antigen, Outer surface protein A (OspA)

The paper identifies unique borreliacidal epitopes on OspA using VHHs and evaluates their reactivity across OspA serotypes.

Structural Elucidation of a Protective B cell Epitope on Outer Surface Protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi

This paper determines the crystal structure of a protective B cell epitope on OspC, revealing its quaternary nature and informing vaccine design for Lyme disease.

The Flexible Linker of Decorin Binding Protein A from Borrelia burgdorferi is a Target of Antibodies in Lyme disease

The paper identifies a specific DbpA epitope targeted by antibodies in Lyme disease patients, suggesting it may block B. burgdorferi colonization.

Sites of Vulnerability on Ricin B Chain Revealed through Epitope Mapping of Toxin-Neutralizing Monoclonal Antibodies

This study identifies the epitopes of two classes of ricin toxin-neutralizing monoclonal antibodies by mapping their binding to specific domains of the RTB subunit.

Intracellular Neutralization of Ricin Toxin by Single Domain Antibodies Targeting the Active Site Pocket

The paper identifies three potent single-domain antibodies that neutralize ricin toxin by targeting its active site, with structural insights into their mechanism of action.

Fine Specificity Epitope Analysis by HX-MS Identifies Contact Points on Ricin Toxin Recognized by Protective Monoclonal Antibodies

This study identifies protective monoclonal antibodies against ricin by mapping their epitopes using HX-MS and shows that specific contact points on RTA correlate with in vivo protection.