D. Kim

Deep-learning-enabled morphodynamic analysis of drug responses in a biomimetic fibrin-based 3D glioblastoma invasion model

This paper develops a 3D glioblastoma model with deep learning to predict drug responses and invasion patterns.

In vivo quantification of anterior and posterior chamber volumes in mice: implications for aqueous humor dynamics

This study measures anterior and posterior chamber volumes in mice, finding the anterior chamber constitutes 47% of total aqueous humor volume, significantly different from humans, and suggests previous inflow rate estimates may be overestimated.

Genetic basis of state-dependent courtship sounds in inbred mice

The paper investigates genetic contributions to courtship sound patterns in mice, finding strain-specific differences in appetitive but not consummatory behaviors.

High-motility pro-tumorigenic monocytes drive macrophage enrichment in the tumor microenvironment

This study identifies high-motility tumor-associated monocytes (TAMos) that drive macrophage infiltration and cancer cell proliferation via IL-6 and MAPK pathways, suggesting IL-6 as a therapeutic target.

Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer

This study shows that ongoing whole-genome doubling in ovarian cancer promotes cell diversity and immune dysregulation through chromosomal instability and quiescent states.

PEPCy: Photostable fluoromodules for live cell, super-resolution microscopy of surface proteins

The paper introduces PEPCy, photostable fluoromodules that enhance cyanine dye photostability for live-cell super-resolution microscopy of surface proteins.

Freeform robotic optical coherence tomography beyond the optical field-of-view limit

This paper introduces a freeform robotic OCT system to overcome the FOV limitation in imaging non-planar anatomies, demonstrating its application in imaging the mouse eye's aqueous humor outflow pathway.

Native Korean wild mice (Mus musculus): molecular phylogeny and morphometrics

The paper analyzes genetic and morphological data of Korean wild mice to determine their phylogenetic relationships and taxonomic status within the Mus musculus subspecies.

Responses to membrane potential-modulating ionic solutions measured by magnetic resonance imaging of cultured cells and in vivo rat cortex

This study uses MRI to measure responses of cultured cells and in vivo rat cortex to ionic solutions that modulate membrane potential, finding changes in T2 relaxation time and bound-to-free water proton ratio.

Matrix-rigidity cooperates with biochemical cues in M2 macrophage activation through increased nuclear deformation and chromatin accessibility

This study shows matrix rigidity enhances M2 macrophage activation by altering nuclear mechanics and chromatin accessibility through cooperation with biochemical signals like IL4/13.

Intrinsic diving reflex induces potent antioxidative response by activation of NRF2 signaling

This study shows that both acute and chronic diving reflex activate NRF2 signaling, with acute exposure inducing stronger antioxidative gene expression than chronic exposure.

Formation of a giant unilocular vacuole via macropinocytosis-like process confers anoikis resistance

The paper shows that disrupting the actin cytoskeleton leads to the formation of a giant unilocular vacuole, which confers anoikis resistance in cells losing matrix attachment.

Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling

This study shows that IPMK regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling, impacting immune responses and autoimmune disease models.

Synaptic plasticity via receptor tyrosine kinase / G protein-coupled receptor crosstalk

The paper identifies a novel form of hippocampal synaptic plasticity mediated by TrkB and mGluR5 crosstalk in response to BDNF.

Sequential genetic, epigenetic alterations in human pluripotent stem cells for recurrent abnormality

The paper investigates genetic and epigenetic changes in human pluripotent stem cells during in vitro culture and identifies 20q11.21 copy number gain and epigenetic modifications as key factors in inducing culture-adapted phenotypes.

Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors

This paper develops velocity receptors (VRs) to enhance CAR T cell migration through solid tumors, improving tumor infiltration and survival.

Combinatorial CRISPR screen reveals FYN and KDM4 as targets for synergistic drug combination for treating triple negative breast cancer

The paper identifies FYN and KDM4 as synergistic targets for enhancing TKI efficacy in triple negative breast cancer through CRISPR screens and mechanistic analysis.

Impact of Memory T Cells on SARS-COV-2 Vaccine Response in Hematopoietic Stem Cell Transplant

This study evaluates SARS-CoV-2 vaccine responses in HSCT recipients, finding memory T cell defects linked to reduced T cell responses despite humoral responses.

The defined TLR3 agonist, Nexavant, exhibits anti-cancer efficacy and potentiates anti-PD-1 antibody therapy by enhancing immune cell infiltration.

This paper evaluates Nexavant, a TLR3 agonist, showing enhanced anti-cancer effects and synergy with anti-PD-1 therapy through immune cell infiltration.

Evaluation of purine-nucleoside degrading ability and in vivo uric acid lowering of Streptococcus thermophilus (ID-PDP3), a novel antiuricemia strain

This study evaluates the purine-nucleoside degrading ability and uric acid lowering effect of Streptococcus thermophilus IDCC 2201 in a rat model of hyperuricemia.

Intronic miR342 is a master regulator of cellular glycolysis in Foxp3+ regulatory CD4 T cells

This study identifies miR-342 as a master regulator of glycolysis in Foxp3+ regulatory T cells, essential for controlling inflammation in the central nervous system.

Soybean RIN4 represents a mechanistic link between plant immune and symbiotic signaling

This paper identifies RIN4 phosphorylation as a critical link between plant immune and symbiotic signaling in soybean, showing its necessity for nodulation and compatibility with rhizobia.

Identifying signals of memory from observations of animal movements

The paper reviews methods to incorporate memory into movement models using wildlife tracking data and provides code examples for implementation.

Endocytosis gated by emergent properties of membrane-clathrin interactions

This paper models clathrin-mediated endocytosis to show that the switch between productive and abortive CCPs is an emergent property of clathrin-membrane interactions and EAPs.

Modeling individual variability in habitat selection and movement using integrated step-selection analyses

The paper develops methods to model individual variability in habitat selection and movement using integrated step-selection analyses with random effects, applied to red snapper data.

A developmentally-inspired hypoxia condition promotes kidney organoid differentiation from human pluripotent stem cells

This study uses hypoxia to improve kidney organoid differentiation from hPSCs, resulting in more mature structures with collecting ducts and potential for disease modeling.

Self-assembling Gn head ferritin nanoparticle vaccine provides full protection from lethal challenge of Dabie Bandavirus in aged ferrets

This paper develops a self-assembling ferritin nanoparticle vaccine targeting DBV Gn head region that fully protects aged ferrets from lethal DBV challenge.

Hepatocyte-specific disruption of soluble epoxide hydrolase attenuates abdominal aortic aneurysm formation: novel role of the liver in aneurysm pathogenesis

This study shows that disrupting soluble epoxide hydrolase (sEH) in the liver prevents abdominal aortic aneurysm (AAA) formation by reducing inflammatory factors like C3 and SAA.

Reproducing Left Ventricular Twist by Mimicking Myocardial Fiber Orientation Using 3D Bioprinting-assisted Tissue Assembly

This paper develops a 3D bioprinting-assisted method to create a chamber-like structure with myocardial fiber orientation, demonstrating left ventricular twist and structural-functional synchrony.

Immune-Epithelial Dynamics and Tissue Remodeling in Chronically Inflamed Nasal Epithelium via Multi-scaled Transcriptomics

This study uses multi-scaled transcriptomics to investigate immune-epithelial dynamics and tissue remodeling in chronic rhinosinusitis, identifying novel cellular interactions and trajectories associated with nasal polyps.