C. J. Roy

Reversion of Ebolavirus Disease from a Single Intramuscular Injection of a pan-Ebolavirus Immunotherapeutic

This study shows that a single intramuscular dose of MBP431, a modified ebolavirus therapeutic, can reverse disease and provide protection in non-human primates.

Myeloid cell-driven nonregenerative pulmonary scarring is conserved in multiple nonhuman primate species regardless of SARS-CoV-2 infection modality

This study shows that nonhuman primates develop similar pulmonary scarring regardless of SARS-CoV-2 infection route, suggesting conserved disease mechanisms.

The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease

This study shows that pigtail macaques infected with SARS-CoV-2 exhibit mild-to-moderate disease with specific immune and viral dynamics, making them a potential model for studying COVID-19.

Intra-host SARS-CoV-2 evolution in the gut of mucosally-infected Chlorocebus aethiops (African green monkeys)

This study tracks SARS-CoV-2 evolution in African green monkeys after respiratory infection, identifying mutations lost in vivo and host-adapted variants.

An Orally Available Cathepsin L Inhibitor Protects Lungs Against SARS-CoV-2-Induced Diffuse Alveolar Damage in African Green Monkeys

This study shows that the orally available cathepsin L inhibitor K777 reduces SARS-CoV-2-induced lung damage in African green monkeys.

Effective prophylaxis of COVID-19 in rhesus macaques using a combination of two parentally-administered SARS-CoV-2 neutralizing antibodies

This study shows that a combination of two SARS-CoV-2 neutralizing antibodies prevents COVID-19 in rhesus macaques, with full protection at a higher dose and partial protection at lower doses.

Phenotypic and Kinetic Changes of Myeloid Lineage Cells in Innate Response to Chikungunya Infection in Cynomolgus Macaques

This study examines kinetic and phenotypic changes in myeloid lineage cells during early Chikungunya infection in cynomolgus macaques, revealing altered cell turnover and activation states.

Particle Dynamics and Bioaerosol Viability of Aerosolized BCG Vaccine Using Jet and Vibrating Mesh Clinical Nebulizers

This paper evaluates four nebulizers for aerosolizing BCG vaccine, finding that vibrating mesh devices maintain stable viability across inoculum concentrations, while jet nebulizers show reduced efficiency at higher concentrations.

Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates

This study examines immune events in non-human primates infected with SARS-CoV-2, identifying cellular correlates of disease severity and potential therapeutic targets.

Acute Respiratory Distress and Cytokine Storm in Aged, SARS-CoV-2 Infected African Green Monkeys, but not in Rhesus Macaques

This study compares SARS-CoV-2 infection in aged African green monkeys and rhesus macaques, finding ARDS and cytokine storms in AGMs but not RMs.

The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection

This paper explores ATN-161 as a potential therapy for SARS-CoV-2 by targeting the interaction between the spike protein and 5β1 integrin, alongside ACE2.