N. Popgeorgiev

Evolution of apoptotic signalling pathways within lophotrochozoans

This study investigates the evolution of apoptotic signalling pathways in lophotrochozoans, revealing diversification and loss of key components across different groups.

Identification of a new Inovirus in the absence of bacterial infection in the human virome

The paper identifies a new Inovirus, RIP1, in the human virome without bacterial infection, showing its presence in multiple body sites.

The Endoplasmic Reticulum pool of Bcl-xL dampens the Unfolded Protein Response through IP3R-dependent Calcium Release

This study shows that Bcl-xL at the endoplasmic reticulum (ER) dampens the unfolded protein response (UPR) by reducing IP3R-mediated calcium release, thereby preventing ER calcium depletion and cell death.

Pleiotropy of Bcl-2 family proteins is an ancient trait in the metazoan evolution

This study identifies Bcl-2 family pleiotropy in Trichoplax adhaerens, showing dual roles in ER calcium regulation and mitochondrial apoptosis.

Failed apoptosis enhances melanoma cancer cells aggressiveness

The paper shows that failed apoptosis in melanoma cells leads to increased aggressiveness through transcriptomic changes and JNK pathway activation, observed in vitro and in vivo.