Cell BiologybioRxivPreprint
The Endoplasmic Reticulum pool of Bcl-xL dampens the Unfolded Protein Response through IP3R-dependent Calcium Release
L. Jabbour, T. Nguyen, R. Gadet…·N. Popgeorgiev
This study shows that Bcl-xL at the endoplasmic reticulum (ER) dampens the unfolded protein response (UPR) by reducing IP3R-mediated calcium release, thereby preventing ER calcium depletion and cell death.
DOI 10.1101/2021.01.27.428229