When is gene expression noise advantageous?
This study shows gene expression noise can be advantageous in fluctuating environments and is influenced by gene network position during evolution.
bioRxiv · Dec 4, 2023 · PreprintEvolutionary Biology
Author
N. Puzovic
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Biology Disciplines
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Recent·Most cited
Being noisy in a crowd: differential selective pressure on gene expression noise in model gene regulatory networks
N. Puzovic, T. Madaan, J. Y. Dutheil
The paper simulates evolution of gene-specific expression noise in gene regulatory networks, finding that central genes experience stronger selective pressure to reduce noise.
bioRxiv · Aug 1, 2022Evolutionary Biology
Inference of recombination maps from a single pair of genomes and its application to archaic samples
G. Valadares Barroso, N. Puzovic, J. Dutheil
This paper introduces a method to infer recombination maps from a single pair of genomes and applies it to archaic hominid samples, showing recombination patterns align with expected neutral evolution.
bioRxiv · Oct 25, 2018Evolutionary Biology
Selection at the pathway level drives the evolution of gene-specific transcriptional noise
G. V. Barroso, N. Puzovic, J. Y. Dutheil
The paper analyzes transcriptional noise in mouse genes using single-cell transcriptomics data to show that pathway position, not just gene properties, drives evolutionary selection on noise levels.
bioRxiv · Oct 7, 2017Evolutionary Biology