Mechano-dependent sorbitol accumulation supports biomolecular condensate
S. Torrino, W. Oldham, A. R. Tejedor, I. Sanchez-Burgos, N. Rachedi, K. Fraissard, C. Chauvet, C. Sbai, B. P. O'Hara, S. Abelanet, F. Brau, S. Clavel, R. Collepardo-Guevara, J. Rene Espinosa, I. ben-sahra, T. BERTERO
The paper shows matrix stiffening promotes biomolecular condensation via sorbitol, a mechanosensitive metabolite, and demonstrates this in breast cancer.
bioRxiv · Jul 24, 2023Cell Biology