T. Bertero

Genetic regulation and targeted reversal of lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension

The paper identifies NCOA7's role in lysosomal function and inflammatory sterol metabolism in PAH, showing its deficiency exacerbates disease through oxysterol/bile acid generation.

Mechano-dependent sorbitol accumulation supports biomolecular condensate

The paper shows matrix stiffening promotes biomolecular condensation via sorbitol, a mechanosensitive metabolite, and demonstrates this in breast cancer.

Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function

This study shows that frataxin deficiency in endothelial cells causes mitochondrial respiration defects and vasoconstriction, contributing to pulmonary hypertension.

The Role of EBP50 in Regulating Endothelial-To-Mesenchymal Transition in Pulmonary Hypertension

This study shows EBP50 downregulation promotes EndMT in pulmonary hypertension by increasing Snail, Zeb1, and Slug expression, and mesenchymal markers, while reducing cell proliferation and barrier function.

UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFRsignaling

This study shows UBTD1 regulates EGFR signaling by controlling ceramide levels and endolysosomal positioning through ubiquitination of ASAH1 and SQSTM1/p62.

Biophysical forces rewire cell metabolism to guide microtubule-dependent cell mechanics

This study shows mechanical forces rewire glutamine metabolism to promote microtubule glutamylation, affecting cell mechanics and mechanodependent functions.