Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity
N. Raffa, T. H. Won, A. Sukowaty, K. Candor, C. Cui, S. Halder, M. Dai, J. A. Landero Figueroa, F. C. Schroeder, N. Keller
This study identifies isocyanides from Aspergillus fumigatus that bind copper, regulate its cellular levels, and exhibit copper-dependent antimicrobial activity.
bioRxiv · Jul 23, 2020Microbiology