M. Dai

BRAT1 - a new therapeutic target for glioblastoma

This study identifies BRAT1 as a key driver of glioblastoma growth and invasion, showing that its inhibition with CurD reduces tumor migration and enhances radiation sensitivity.

Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19

The paper identifies a potent orally bioavailable SARS-CoV-2 PLpro inhibitor with in vitro and in vivo antiviral activity against SARS-CoV-2 and related coronaviruses.

Peptide Amphiphiles Hitchhike on Endogenous Biomolecules for Enhanced Cancer Imaging and Therapy

This study demonstrates that peptide amphiphile nanostructures enhance cancer imaging and therapy by hitchhiking on endogenous biomolecules to target tumors effectively.

A dipteran parasite regulates 20E synthesis and antibacterial activity of the host for development through inducing host nitric oxide production

This study shows that a dipteran parasite increases host nitric oxide production to regulate 20E synthesis and antibacterial activity, supporting its development.

Mitochondrial genome evolution in the Diprionidae: Major gene rearrangement in the basal Hymenoptera

The paper examines mitochondrial gene rearrangements in Diprionidae, showing their potential as phylogenetic markers in Hymenoptera evolution.

A Unified Catalog of 19,251 Non-human Reference Species Genomes Provides New Insights into the Mammalian Gut Microbiomes

The paper catalogs 19,251 non-human reference genomes from Qinghai-Tibetan Plateau animals, revealing new insights into mammalian gut microbiome diversity and host-microbe interactions.

LIPA-driven hydrolysis of cholesteryl arachidonate promotes cancer metastasis via NF-κB

This study identifies LIPA as a key regulator of CE hydrolysis in cancer cells, showing that its inhibition suppresses metastasis via suppression of NF-κB signaling.

Structural insights into the activation of human calcium-sensing receptor

The paper presents cryo-EM structures of the human calcium-sensing receptor in inactive and active states, revealing structural changes during activation.

Phage Display Broadly Identifies Inhibitor-reactive Regions in von Willebrand Factor

This study uses phage display and NGS to identify inhibitor-reactive regions in von Willebrand factor, revealing distinct patterns among patients and overlap with a commercial antibody.

Emergence of a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Co-harbouring a blaNDM-1-carrying Virulent Plasmid and a blaKPC-2-carrying Plasmid in an Egyptian Hospital

This study identifies a hypervirulent CRKP strain in Egypt carrying two plasmids with carbapenemase and virulence genes, highlighting the genetic basis of resistance and virulence.

Chicken peripheral blood lymphocyte response to ALV-J infection assessed by single-cell RNA sequencing

This study uses single-cell RNA sequencing to analyze chicken peripheral blood lymphocytes infected with ALV-J, identifying T cell subsets and their molecular responses to infection.

Co-infection of influenza A virus enhances SARS-CoV-2 infectivity

This study shows that influenza A virus pre-infection increases SARS-CoV-2 infectivity in multiple cell types and worsens lung damage in mice.

Long-term survival of salmon-attached SARS-CoV-2 at 4 degree as a potential source of transmission in seafood markets

This study shows that SARS-CoV-2 attached to salmon can remain infectious for over a week at 4°C, indicating a potential transmission risk in seafood markets.

Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity

This study identifies isocyanides from Aspergillus fumigatus that bind copper, regulate its cellular levels, and exhibit copper-dependent antimicrobial activity.

PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin

The paper identifies PFN2 as a specific regulator of NAA80, enhancing its catalytic activity and promoting actin N-terminal acetylation.

Reconstruction and dynamics of human intestinal microbiome observed in situ

This study samples ileocecal microbiome in situ using transendoscopic tubing and finds distinct metatranscriptomes compared to fecal samples, diurnal rhythms in bacterial activity, and metabolomic parallels to gut microbiome changes.

Endosidin20 targets cellulose synthase catalytic domain to inhibit cellulose biosynthesis

Endosidin20 inhibits cellulose synthesis by targeting the catalytic site of CESA6, reducing cellulose synthase complex delivery to the plasma membrane.

Dynamics of mcr-1 prevalence and mcr-1-positive Escherichia coli after the cessation of colistin use as a feed additive for animals in China: a prospective cross-sectional and whole genome sequencing based molecular epidemiological study

This study tracks the decline of mcr-1 prevalence and genetic changes in mcr-1-positive Escherichia coli after China banned colistin use in animal feed.

DNA 5-Hydroxymethylcytosines from Cell-free Circulating DNA as Diagnostic Biomarkers for Human Cancers

The paper identifies 5hmC signatures in cfDNA as accurate biomarkers for detecting colorectal and gastric cancers, outperforming conventional markers and matching tissue biopsy results.

Rapid Sequential In Situ Multiplexing With DNA-Exchange-Imaging

This paper introduces DNA-Exchange-Imaging, a method for rapid, highly multiplexed in situ protein visualization, achieving sub-20 nm resolution and reducing imaging time from days to minutes.

T-bet+ CD11c+ B Cells Are Critical For Anti-Chromatin IgG Production In The Development Of Lupus