C. Cui

IL-4 Licenses B Cell Activation Through Cholesterol Synthesis

This study shows IL-4 promotes B cell activation by upregulating cholesterol synthesis, which is essential for ER expansion, cell cycle progression, and proliferation during influenza infection.

Mesenchymal stem cell-derived extracellular vesicles attenuate symptoms in dextran sodium sulfate-induced ulcerative colitis mouse model

This study shows that mesenchymal stem cell-derived extracellular vesicles reduce symptoms in a dextran sulfate sodium-induced ulcerative colitis mouse model by repairing colon mucosa and reducing macrophage infiltration.

GENOMES UNCOUPLED1: an RNA-binding protein required for early PSII biogenesis

This study identifies psbD BLRP as a target RNA of GUN1, an RNA-binding protein essential for early PSII biogenesis during seedling development.

Harnessing extracellular vesicles for efficient siRNA delivery in vitro and in vivo

This study develops an efficient siRNA delivery system using extracellular vesicles, demonstrating effective gene silencing in vitro and tumor growth inhibition in vivo.

Effect and mechanism of black soybean peptides alleviating oxidative damage in the celiac disease cell model

This study investigates how black soybean peptides alleviate oxidative damage caused by alpha gliadin peptide in a celiac disease cell model.

Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling

This study creates a single-cell atlas of the bone microenvironment in healthy and inflammatory states, identifying key MSC subclusters and their biomarkers in apical periodontitis.

Combating pancreatic cancer with ovarian cancer cells

This study shows ovarian cancer cells inhibit pancreatic cancer growth in vitro and in vivo, with enhanced effects from elephant TP53 gene expression, suggesting a novel non-immunotherapy approach for pancreatic cancer treatment.

Locomotion control during curb descent: Bilateral ground reaction variables covary consistently during the double support phase regardless of future foot placement constraints

This study examines how ground reaction forces and moments coordinate during the double support phase of curb descent, finding that stability of whole-body rotations is prioritized over future foot placement constraints.

Humans prioritize walking efficiency or walking stability based on environmental risk

The paper shows humans adjust step length to balance walking efficiency and stability based on environmental risk.

Multiplexed imaging mass cytometry reveals distincttumor-immune microenvironments linked to immunotherapyresponses in melanoma

This study uses imaging mass cytometry to analyze tumor-immune microenvironments in melanoma patients, identifying distinct microenvironment archetypes linked to responses to anti-PD-1 therapy.

The PD-1 checkpoint receptor maintains tolerance of self-reactive CD8 T cell in skin

The paper shows that PD-1+ CD8 T cells in healthy skin remain tolerant to self-antigens and prevent tissue damage through PD-L1 upregulation on myeloid cells.

A Versatile Linker for Probes Targeting Hydrolases via In Situ labeling

This study develops a versatile linker chemistry for in situ labeling of hydrolase-targeting probes using quinone methide species, showing improved labeling efficiency in living cells.

Generation of functional ciliates cholangiocytes from human pluripotent stem cells

This study generates functional cholangiocytes from human pluripotent stem cells that exhibit mature characteristics and can be used for drug testing and disease modeling.

Precartilage condensation during limb skeletogenesis occurs by tissue phase separation controlled by a bistable cell-state switch with suppressed oscillatory dynamics

The paper shows that precartilage condensation in limb development occurs via a bistable cell-state switch driven by galectins, without oscillatory dynamics.

Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors

The paper identifies two non-canonical GPCRs, D6R and C5aR2, that exclusively couple to β-arrestins and exhibit distinct GRK preferences and downstream signaling.

A reservoir of stem-like CD8 T cells in the tumor-draining lymph node maintains the ongoing anti-tumor immune response

The paper identifies a reservoir of stem-like CD8 T cells in tumor-draining lymph nodes that sustain anti-tumor immunity by maintaining TCF1 expression and resisting terminal differentiation.

Neoantigen-driven B cell and CD4+ T follicular helper cell collaboration promotes robust anti-tumor CD8+ T cell responses

This study shows that TFH-B cell interactions driven by neoantigens enhance anti-tumor CD8+ T cell responses in lung adenocarcinoma.

Tubular lysosomes harbor active ion gradients and poise macrophages for phagocytosis

This study identifies tubular lysosomes in macrophages as having ion gradients that prepare them for phagocytosis without activating the cells.

Ribonucleotide reductase, a novel target for gonorrhea

This study identifies two novel inhibitors of Neisseria gonorrhoeae that target ribonucleotide reductase, showing efficacy against multidrug-resistant strains in a mouse model.

Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity

This study identifies isocyanides from Aspergillus fumigatus that bind copper, regulate its cellular levels, and exhibit copper-dependent antimicrobial activity.

Population Pharmacokinetics of an Anti-PD-1 Antibody Camrelizumab in Patients with Multiple tumor types and model informed dosing strategy

This paper performs population pharmacokinetics analysis of camrelizumab and finds no significant advantage of flat-dose or weight-based dosing regimens.

Single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated fibroblasts

The paper identifies a cellular transition from adipose-derived stromal cells to COL11A1-expressing cancer-associated fibroblasts across multiple cancers using single-cell analysis.

Cytotoxicity evaluation of chloroquine and hydroxychloroquine in multiple cell lines and tissues by dynamic imaging system and PBPK model

This study evaluates the cytotoxicity of chloroquine and hydroxychloroquine in multiple cell lines and tissues using a dynamic imaging system and PBPK model, finding HCQ less toxic than CQ in most cases.

Ratio of the interferon-γ signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma

The paper identifies an immunosuppression signature (IMS) and shows that its ratio to an IFN-γ signature better predicts anti-PD-1 therapy response in melanoma than existing biomarkers.

A Self-Immobilizing NIR Probe for Non-invasive Imaging of Senescence

The paper develops a self-immobilizing NIR probe activated by SA-β-Gal for non-invasive imaging of senescence in mice.

Ultrasensitive small molecule fluorogenic probe for human heparanase

This paper introduces an ultrasensitive fluorogenic probe for detecting human heparanase activity with a picomolar detection limit and demonstrates its use in high-throughput inhibitor screening.

A common problem in the purification of calicivirus raised by molecular sieving: balance between purification and loss of viral particles

This study evaluates the impact of molecular sieving on Feline Calicivirus stability using cryo-EM and develops a scoring system to assess purification effects.

Responsive fluorophore aggregation provides spectral contrast for fluorescence lifetime imaging

The paper develops a fluorescent probe that changes emission lifetime upon aggregation, demonstrating potential for responsive imaging probes.

NINJA: an inducible genetic model for creating neoantigens in vivo

The paper develops a genetic model called NINJA to create inducible neoantigens in mice, enabling controlled T cell responses without central tolerance.

Biocontrol of PGPR strain Bacillus amyloliquefaciens Ba168 against Phytophthora nicotianae on tobacco

This paper evaluates the biocontrol potential of PGPR strain Ba168 against tobacco black shank caused by Phytophthora nicotianae, showing it is effective but slightly less than a chemical mixture.