Structure of the ForT/PRPP complex uncovers the mechanism of C-C bond formation in C-nucleotide antibiotic biosynthesis
S. Gao, A. Radadiya, W. Li, H. Liu, W. Zhu, V. de Crecy-Lagard, N. Richards, J. Naismith
The paper reports the structure of the ForT/PRPP complex and identifies residues critical for catalysis, proposing a mechanism for C-C bond formation in C-nucleotide antibiotic biosynthesis.
bioRxiv · Mar 26, 2020 · PreprintBiochemistry