S. Gao

Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss

The paper investigates gene loss in Vibrio parahaemolyticus pandemic clones, showing it drives wave succession through environmental and transmission advantages.

Opto-chemogenetic inhibition of L-type CaV1 channels in neurons through a membrane-assisted molecular linkage

This paper develops a method to inhibit L-type CaV1 channels in neurons using opto-chemogenetic tools, showing acute and potent inhibition through membrane-assisted molecular linkage.

pH-Controlled chemoselective rapid azo-coupling reaction (CRACR) enables global profiling of serotonylation proteome in cancer cells

The paper develops a chemical proteomic method to globally profile serotonylation in cancer cells, identifying over 1,000 serotonylated proteins and their modification sites.

Chemical proteomic profiling of protein dopaminylation in colorectal cancer cells

The paper identifies 425 dopaminylated proteins in colorectal cancer cells using a chemical probe, revealing their involvement in nucleic acid metabolism and transcription, and suggests targeting protein dopaminylation as a potential anti-cancer strategy.

The enhancement of electricity generation using cellulose based on ternary microbial consortium

This paper demonstrates that a ternary microbial consortium enhances electricity generation from cellulose by synergistically converting it to acetate and using riboflavin as an electron shuttle.

Bioorthogonal labeling and enrichment of histone monoaminylation reveal its accumulation and regulatory function in cancer cell chromatin

This study develops chemical probes to label and enrich histone monoaminylation, revealing its enrichment in cancer tissues and its role in chromatin architecture regulation.

HER2 Prognostic Significance and Therapeutic Implications in Gastric Cardia Adenocarcinoma: Insights from Multi-Omics Profiling

This study identifies HER2 as a prognostic marker in GCA and suggests anti-inflammatory and immune checkpoint inhibition as therapeutic strategies for HER2-negative patients.

Enhanced microbiota profiling in patients with quiescent Crohn's disease through comparison with paired healthy first-degree relatives using fecal metagenomics and metabolomics

The paper compares microbiota and metabolome profiles of quiescent Crohn's disease patients with their healthy first-degree relatives to identify biomarkers associated with disease relapse.

GhCPK28 negatively regulates the immune response by phosphorylating GhTIFY3b

This study identifies GhCPK28 as a negative regulator of cotton immunity against Verticillium dahliae by phosphorylating and destabilizing GhTIFY3b, enhancing resistance when silenced.

Biochemical and Structural Characterization of Fapy·dG Replication by Human DNA Polymerase β

This study investigates how human DNA polymerase β processes the mutagenic lesion Fapy*dG during DNA replication, showing inefficient bypass and incorporation, suggesting mutagenicity arises from bypass rather than lesion incorporation.

Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168

This study determines the cryo-EM structures of RNF168/UbcH5c-Ub/nucleosome complexes to elucidate the mechanism of H2A K13/K15 site-specific ubiquitination.

A Day in the Life of Arabidopsis: 24-Hour Time-lapse Single-nucleus Transcriptomics Reveal Cell-type specific Circadian Rhythms

This study uses snRNA-seq to analyze circadian rhythms in Arabidopsis over 24 hours, revealing cell-type specific gene expression patterns and identifying key circadian regulators.

Application of slow-controlled release fertilizer coordinates the carbon flow in carbon-nitrogen metabolism to effect rice quality

This study evaluates five slow-controlled release fertilizers on rice quality over two years, finding that BBF improves yield and grain quality by optimizing carbon-nitrogen metabolism.

High-fidelity, generalizable light-field reconstruction of biological dynamics with physics-informed meta neural representation

This paper introduces LFMNR, a method for high-fidelity 3D reconstruction of biological dynamics using physics-informed neural representations and meta-learning, achieving improved resolution and speed.

Structure and mechanism of the human CTDNEP1-NEP1R1 membrane protein phosphatase complex necessary to maintain ER membrane morphology

This study identifies CTDNEP1-NEP1R1 as a conserved membrane phosphatase complex that restricts ER expansion, with NEP1R1 activating CTDNEP1 through structural stabilization and substrate orientation.

Differential reliance of CTD-nuclear envelope phosphatase 1 on its regulatory subunit in ER lipid synthesis and storage

This study shows that CTDNEP1's regulatory subunit NEP1R1 controls its degradation to regulate ER membrane synthesis via lipin 1, but not lipid droplet biogenesis.

Boosting Ascomycin Production through n-Butanol Addition in the Fermentation Process of Streptomyces hygroscopicus var. ascomyceticus ATCC 14891

This study enhances FK520 production in Streptomyces hygroscopicus by adding n-butanol, increasing yield by 1.72-fold and boosting precursor accumulation.

Haplotype independence contributes to evolvability in the long-term absence of sex in a mite

The paper identifies haplotypic independence as a mechanism enabling long-term survival of an asexual mite species without sex.

SenePy: Unveiling the Cell-Type Specific Landscape of Cellular Senescence through Single-Cell Analysis in Living Organisms

SenePy identifies cell-type specific senescence signatures from single-cell data, improving senescent cell detection in vivo and revealing increased senescence in diseases like COVID-19 and myocardial infarction.

Semantic redundancy-aware implicit neural compression for multidimensional biomedical image data

This paper introduces SINCS, a compression method for multidimensional biomedical images that improves efficiency and quality by leveraging semantic redundancy and saliency maps.

Endothelial SARS-CoV-2 infection is not the underlying cause of COVID19-associated vascular pathology in mice

This study shows that endothelial SARS-CoV-2 infection does not significantly contribute to COVID-19-associated vascular pathology in mice.

Diminishing neuronal acidification by channelrhodopsins with low proton conduction

The paper identifies and characterizes channelrhodopsins with low proton permeability to mitigate neuronal acidification during optogenetic stimulation.

Multimodal meta-analysis of fecal metagenomes reveals microbial single nucleotide variants as superior biomarkers for early detection of colorectal cancer

This study identifies microbial single nucleotide variants (SNVs) as superior biomarkers for early detection of colorectal cancer, outperforming species-level signatures in multiple validation cohorts.

Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance

This study shows that combining KRASG12C and SOS1 inhibitors improves anti-tumor response and delays resistance in KRASG12C-driven cancers.

Characterization of fluorescence lifetime of organic fluorophores for molecular imaging in the SWIR window

The paper characterizes the brightness and fluorescence lifetime of SWIR fluorophores and compares them to NIR probes, demonstrating the feasibility of lifetime multiplexing in the SWIR window.

Mechanical force induces DRP1-dependent asymmetrical mitochondrial fission for quality control

The paper shows mechanical force induces DRP1-dependent asymmetrical mitochondrial fission, leading to mtDNA-free fragments that recruit Parkin proteins.

The molecular mechanism of chloramphenicol and thiamphenicol resistance mediated by a novel oxidase CmO in Sphingomonadaceae

This paper identifies and characterizes a novel oxidase gene cmO in Sphingomonadaceae that mediates chloramphenicol and thiamphenicol resistance through oxidative inactivation.

Metformin Alleviates Arthrofibrosis in Rat via Fibroblast Metabolic Reprogramming

This study shows metformin reduces arthrofibrosis in rats by altering fibroblast metabolism, shifting it from oxidative phosphorylation to aerobic glycolysis.

Noninvasive cancer detection by extracting and integrating multi-modal data from whole-methylome sequencing of plasma cell-free DNA

This paper develops a method to detect cancer noninvasively by integrating methylation, fragmentation, and copy number data from plasma cell-free DNA using machine learning.

Physiology and structure of pathogenic Escherichia coli pOmpT reveal two substrate-binding sites

The paper identifies two substrate-binding sites in pOmpT that enable specific cleavage of human AMP RNase 7, revealing structural basis for substrate specificity and drug development clues.