Correction of non-random mutational biases along a linear bacterial chromosome by the mismatch repair endonuclease NucS
O. Dagva, A. Thibessard, J.-N. Lorenzi, V. Labat, E. Piotrowski, N. Rouhier, H. Myllykallio, P. Leblond, C. Bertrand
This study shows that NucS, a mismatch repair endonuclease in Streptomyces, reduces mutation rates by correcting G/T mismatches and influences the mutational spectrum along the chromosome.
bioRxiv · Dec 20, 2023Microbiology