FOXP3+ regulatory T cells use heparanase to access IL-2 bound to ECM in inflamed tissues
H. A. Martinez, I. Koliesnik, G. Kaber, N. Nagy, G. Barlow, B. A. Falk, J. K. Reid, C. O. Medina, A. Hargil, I. Vlodavsky, J.-p. Li, M. Perez-Cruz, S.-W. Tang, E. H. Meyer, L. E. Wrenshall, , H. F. Kuipers
The paper shows FOXP3+ Treg use heparanase to access IL-2 bound to ECM in inflamed tissues, enhancing their function and stability.
bioRxiv · Feb 26, 2023Immunology