Cancer BiologybioRxiv
Enhancer Reprogramming Confers Dependence on Glycolysis and IGF signaling in KMT2D Mutant Melanoma
M. Maitituoheti, E. Keung, M. Tang…·K. Rai
This study identifies KMT2D as a tumor suppressor in melanoma, showing its loss leads to metabolic reprogramming toward glycolysis and dependence on IGF signaling, suggesting therapeutic targeting of these pathways.
DOI 10.1016/j.celrep.2020.108293