A. Shah

A prelimbic molecular clock of protein synthesis for memory persistence

This study identifies a molecular clock in the prelimbic cortex that regulates protein synthesis for memory consolidation and reconsolidation through distinct translational pathways.

Interaction with IP6K1 supports pyrophosphorylation of substrate proteins by the inositol pyrophosphate 5-IP7

The paper shows that IP6K1 interacts with proteins that undergo pyrophosphorylation and with CK2, enabling coordinated pre-phosphorylation and pyrophosphorylation of target serine residues.

A novel nested gene Aff3ir participates in vascular remodelling by enhancing endothelial cell differentiation in mice

This study identifies Aff3ir as a novel gene involved in endothelial cell differentiation by enhancing vascular stem/progenitor cell differentiation in mice.

KatG catalase deficiency confers bedaquiline hyper-susceptibility to isoniazid resistant Mycobacterium tuberculosis

This study identifies KatG catalase deficiency in INH-resistant M. tuberculosis as a factor contributing to hyper-susceptibility to bedaquiline.

Comparative Analysis of Molecular Pathogenic Mechanisms and Antiviral Development Targeting Old and New World Hantaviruses

This study compares molecular mechanisms and antiviral targets of Old and New World hantaviruses using human cell models and identifies potential therapeutic compounds.

Beyond Alternans: Detection of Higher-Order Periodicity in Ex-Vivo Human Ventricles Before Induction of Ventricular Fibrillation

The paper detects higher-order periodicities (period-4, 5, 6, 8) in ex-vivo human ventricles before ventricular fibrillation induction using optical mapping and computational analysis.

Computational ranking-assisted identification of Plexin-B2 in homotypic and heterotypic clustering of circulating tumor cells in breast cancer metastasis

This study identifies Plexin-B2 as a driver of homotypic and heterotypic CTC clusters in breast cancer metastasis, with high expression linked to poor prognosis and therapeutic potential.

Bacterial mixed cultures followed mixed-order kinetics during mono-azo dye decolourization and degradation in batch studies

The paper analyzes the kinetic and thermodynamic behavior of bacterial mixed cultures decolorizing Reactive violet 5R dye in batch studies, finding mixed-order kinetics and non-spontaneity at lower temperatures.

Interference with the HNF4-dependent gene regulatory network diminishes ER stress in hepatocytes

The paper identifies HNF4-dependent genes suppressed by ER stress in the liver and shows that HNF4 deletion reduces UPR activation and ER stress.

Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge

This study shows cytokine-induced degradation of ERG in lung endothelial cells leads to vascular hyperpermeability and inflammation during infection.

Broad-spectrum antiviral inhibitors targeting pandemic potential RNA viruses

This study identifies broad-spectrum antiviral agents effective against multiple RNA virus families, including arboviruses and respiratory pathogens.

A comprehensive update to the Mycobacterium tuberculosis H37Rv reference genome

The paper updates the M. tuberculosis H37Rv reference genome using Bact-Builder, revealing 6.4 kb of new sequence and ten new regions in widely used strains.

Reward quantity discrimination in an associative learning task in wild zebrafish (Danio rerio)

This study tests reward quantity discrimination in wild zebrafish using an operant conditioning task and finds some fish can discriminate between stimuli associated with different rewards.

Evaluation of the antimicrobial, anti-adhesion, anti-biofilm and cell proliferation assay of a de-novo goji berry extract against periodontal pathogens: a comparative in-vitro study

This study evaluates the antimicrobial, anti-adhesion, anti-biofilm, and cytotoxic properties of a goji berry extract against periodontal pathogens in vitro, finding it comparable to chlorhexidine but less effective than doxycycline.

Lem2 is essential for cardiac development by maintaining nuclear integrity

This study shows Lem2 is essential for cardiac development by maintaining nuclear integrity, as its absence leads to DNA damage, nuclear rupture, and apoptosis in mouse hearts.

Nrf2 attenuates the innate immune response after experimental myocardial infarction

This study shows that Nrf2 reduces inflammation after myocardial infarction by suppressing pro-inflammatory cytokines and chemokines in mice.

MK2 Expression Promotes Non-Small Cell Lung Cancer Cell Death and Predicts Survival

This study shows MK2 promotes apoptosis in non-small cell lung cancer by facilitating caspase 3 nuclear translocation, and higher MK2 expression correlates with better patient survival.

Genomic and experimental evidence that alternate transcription initiation of the Anaplastic Lymphoma Kinase (ALK) kinase domain does not predict single agent sensitivity to ALK inhibitors.

The paper reanalyzes ALKATI's role in melanoma using genomic and experimental methods, finding it does not predict single-agent ALK inhibitor sensitivity.

Sesamol and its derivative investigated as antiandrogen - A potential prevention to prostate cancer in rats

This study investigates sesamol and its derivative 3-MA as antiandrogens to prevent prostate cancer in rats by evaluating their effects on androgen receptor interactions and gene expression.

Ultrastructural insight into SARS-CoV-2 attachment, entry and budding in human airway epithelium

This study uses electron microscopy to examine SARS-CoV-2 infection in human airway epithelium, showing viral entry through the plasma membrane and budding from intracellular compartments.

Functional insights of two MATE transporters from Vibrio fluvialis

This study characterizes H- and D-type MATE transporters from Vibrio fluvialis, revealing their substrate specificity, ion dependence, and inhibition by reserpine.

Niobium Carbide Loaded by Macrophage for Targeted Phototherapy Ablation of Breast Cancer

The paper was removed due to copyright violation and fraudulent authorship.

Clinical positioning of the IAP antagonist tolinapant (ASTX660) in colorectal cancer

This study shows tolinapant, an IAP inhibitor, enhances chemotherapy-induced apoptosis in colorectal cancer by modulating FLIP and HDACs, suggesting its clinical use in poor prognosis MSS CRC with elevated cIAP1/2.

Disruption of a GATA2, TAL1, ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

The paper identifies a GATA2, TAL1, ERG regulatory circuit that promotes erythroid transition in both healthy and leukemic stem cells, showing its persistence in AML with minor alterations.

A roadmap for the characterization of energy metabolism in human cardiomyocytes derived from induced pluripotent stem cells

This study characterizes the metabolic profile of hiPSC-CM during maturation, showing increased oxidative capacity and altered substrate utilization over 12 weeks.

Mantis shrimp rank the shape of an object over its color during recognition

This study shows that mantis shrimp prioritize shape over color when recognizing objects, using the species Neogonodactylus oerstedii in controlled experiments.

Elucidating the mechanism of cyclodextrins in the treatment of Niemann-Pick Disease Type C using crosslinked 2-hydroxypropyl-β-cyclodextrin

This study investigates the mechanism of crosslinked 2-hydroxypropyl-β-cyclodextrin (HPβCD) in treating Niemann-Pick Disease Type C and evaluates its in vivo efficacy with MRIg-FUS to enhance brain penetration.

IP6K1 upregulates the formation of processing bodies by promoting proteome remodeling on the mRNA cap

This study shows IP6K1 promotes P-body formation by enhancing translation suppression through interactions with decapping and initiation complex proteins.

Gatekeeper transcription factors regulate switch between lineage preservation and cell plasticity

This study identifies Snai2 and Prrx1 as critical regulators of mesenchymal commitment in rat cells and shows their knockdown can reprogram cells into adipocytes, chondrocytes, osteocytes, or pluripotent stem-like cells without exogenous factors.

A pyro-phosphodegron controls MYC polyubiquitination to regulate cell survival

This study identifies a pyro-phosphodegron in MYC that regulates its polyubiquitination and degradation, affecting cell survival under stress and mitogenic conditions.