F. Muller

The ANKS3/BICC1 protein complex is a master post-transcriptional regulator of NPHP1 ciliopathy gene transcripts

The paper identifies ANKS3/BICC1 as a post-transcriptional regulator of NPHP1 transcripts, linking it to ciliopathy phenotypes through transcript decay and ciliary dysfunction.

Titers of antibodies the receptor-binding domain (RBD) of ancestral SARS-CoV-2 are predictive for levels of neutralizing antibodies to multiple variants

This study shows that anti-RBDwt titers correlate with neutralizing antibody levels against multiple SARS-CoV-2 variants and proposes a method to improve immunomonitoring precision and throughput.

Automatic Detection of Larval Zebrafish ECG: Computational Tool for High-throughput Cardiac Activity Analysis

The paper develops an automated MATLAB-based tool for analyzing larval zebrafish ECG, showing improved sensitivity and efficiency compared to existing methods.

Network Analysis Of Inflammatory Bowel Disease Reveals PTPN2 As New Monogenic Cause Of Intestinal Inflammation

The paper uses network analysis to identify PTPN2 as a new monogenic cause of intestinal inflammation by integrating monogenic and polygenic IBD data.

Super-enhancer impairment is a link between MLL4 inactivated lung tumors and their vulnerability to glycolysis pathway inhibition

The paper shows that MLL4 loss in lung cancer promotes glycolysis and that inhibiting glycolysis selectively targets MLL4-mutant lung tumors.

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF signaling in KMT2D Mutant Melanoma

This study identifies KMT2D as a tumor suppressor in melanoma, showing its loss leads to metabolic reprogramming toward glycolysis and dependence on IGF signaling, suggesting therapeutic targeting of these pathways.