Targeting the catalytic activity of HDAC1 in T cells protects against experimental autoimmune encephalomyelitis
C. Zhu, V. Stolz, N. Simonovic, O. Al-Rubaye, T. Vcelkova, V. Moos, L. Hess, A. Hagelkrueys, M. Madern, W. Reiter, A. Meixner, C. Bock, M. Hartl, W. Ellmeier, C. Seiser
This study shows that inhibiting HDAC1 catalytic activity in T cells prevents experimental autoimmune encephalomyelitis by reducing proinflammatory cytokines and effector functions.
bioRxiv · Apr 14, 2023 · PreprintImmunology