Author

N. Waxham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Approach:deep learning· 2 Approach:microscopy & imaging analysis· 2 Research Focus:benchmarking· 1 Research Focus:dimensionality reduction· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

F. A. Heberle· 4 shared I. Levental· 2 shared M. Doktorova· 2 shared A. D. Skinkle· 1 shared A. E. Ward· 1 shared C. Purnell· 1 shared D. Sokovikova· 1 shared H. L. Scott· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersBiophysics

F. A. Heberle

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Author profile →

4 papers

Recent·Most cited

Cryo-EM images of phase separated lipid bilayer vesicles analyzed with a machine learning approach

K. D. Sharma, M. Doktorova, N. Waxham, F. A. Heberle

This paper develops a machine learning approach to identify phase-separated lipid domains in cryo-EM images with high accuracy.

Biophysical Journal · Sep 1, 2024Peer-reviewedBiophysics

Rapid Synthesis of Cryo-ET Data for Training Deep Learning Models

C. Purnell, J. Heebner, M. T. Swulius, R. Hylton, S. Kabonick, M. Grillo, S. Grigoryev, F. A. Heberle, N. Waxham, M. T. Swulius

This paper introduces a method to generate synthetic Cryo-ET data for training deep learning models, enabling accurate restoration and segmentation of real tomograms.

bioRxiv · Apr 28, 2023 · PreprintCell Biology

Serinc5 restricts HIV membrane fusion by altering lipid order and heterogeneity in the viral membrane

A. E. Ward, D. Sokovikova, N. Waxham, F. A. Heberle, I. Levental, K. R. Levental, V. Kiessling, J. M. White, L. K. Tamm

This study shows Serinc5 restricts HIV infection by altering viral membrane lipid order and heterogeneity, reducing fusion pore formation and infectivity.

bioRxiv · Aug 25, 2022Biophysics

Direct label-free imaging of nanodomains in biomimetic and biological membranes by cryogenic electron microscopy

F. A. Heberle, M. Doktorova, H. L. Scott, A. D. Skinkle, N. Waxham, I. Levental

This paper uses cryoEM to directly image nanodomains in biomimetic and biological membranes without extrinsic probes, revealing structural differences at sub-angstrom resolution.

bioRxiv · Feb 5, 2020Biophysics