M. Doktorova

Cryo-EM images of phase separated lipid bilayer vesicles analyzed with a machine learning approach

This paper develops a machine learning approach to identify phase-separated lipid domains in cryo-EM images with high accuracy.

Cell Membranes Sustain Phospholipid Imbalance Via Cholesterol Asymmetry

The paper reveals that mammalian plasma membranes have phospholipid imbalances due to cholesterol asymmetry, affecting membrane permeability and protein localization.

Efficient calculation of orientation-dependent lipid dynamics from membrane simulations

This paper introduces a framework to efficiently calculate orientation-dependent lipid dynamics from membrane simulations, showing agreement with experimental data and validating a computational protocol linking simulations to NMR spectroscopy.

Molecular Simulations and NMR Reveal How Lipid Fluctuations Affect Membrane Mechanics

This paper uses molecular simulations and NMR to show how lipid fluctuations affect membrane mechanics by linking dynamics to elastic properties.

Ca2+-dependent mechanism of membrane insertion and destabilization by the SARS-CoV-2 fusion peptide

This study identifies Ca2+-dependent mechanisms of SARS-CoV-2 fusion peptide membrane insertion and destabilization through molecular dynamics simulations.

Direct label-free imaging of nanodomains in biomimetic and biological membranes by cryogenic electron microscopy

This paper uses cryoEM to directly image nanodomains in biomimetic and biological membranes without extrinsic probes, revealing structural differences at sub-angstrom resolution.

A new computational method for membrane compressibility: Bilayer mechanical thickness revisited

The paper introduces a new computational method to estimate area compressibility moduli of lipid bilayers using MD simulations and validates it against experimental data and existing models.

Gramicidin increases lipid flip-flop in symmetric and asymmetric lipid vesicles

This study shows gramicidin increases lipid flip-flop in both symmetric and asymmetric lipid vesicles through concentration-dependent mechanisms.