Genotype-phenotype correlations and de novo induction of cancer stem cells in Wilms tumor initiation.
N.S. Pop, Daniëlle Koot, Conny M. Brouwers, Margot M. L. Linssen, Jill W. C. Claassens, C.W.J. Cartlidge, Derya Deniz Ozdemir, Karamjit Singh Dolt, Peter Hohenstein
This study identifies genotype-phenotype correlations in Wilms tumor by analyzing genetically engineered mouse models with Wt1 loss or LIN28B overexpression, showing how these mutations induce cancer stem cell markers.
bioRxiv · Nov 19, 2025 · PreprintDevelopmental Biology