Karamjit Singh Dolt

The paper quantifies signalling effects of CTNNB1 mutations across cancer types and finds weakly activating mutations correlate with worse prognosis in hepatocellular carcinoma.

This study identifies genotype-phenotype correlations in Wilms tumor by analyzing genetically engineered mouse models with Wt1 loss or LIN28B overexpression, showing how these mutations induce cancer stem cell markers.

This study generates p75NTR knockout rats to investigate its role in development and fertility, finding it largely dispensable for normal function.

This study introduces a G51D mutation in the rat Snca gene, leading to synaptic mislocalization of α-synuclein and increased susceptibility to Lewy-like pathology.

This study uses 18F-DOPA PET imaging to identify a dopaminergic deficit in a rat model with a G51D α-synuclein mutation, showing reduced dopamine turnover and striatal asymmetry in aged animals.

This study uses midbrain organoids from SNCA triplication patients to model synucleinopathy features, showing increased alpha-synuclein expression and aggregation linked to dopaminergic neuron loss.