Derya Deniz Ozdemir

The paper quantifies signalling effects of CTNNB1 mutations across cancer types and finds weakly activating mutations correlate with worse prognosis in hepatocellular carcinoma.

This study identifies genotype-phenotype correlations in Wilms tumor by analyzing genetically engineered mouse models with Wt1 loss or LIN28B overexpression, showing how these mutations induce cancer stem cell markers.