Cancer BiologyCancer CellPeer-reviewed
Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies
Tongchen He, Lanbo Xiao, Yuanyuan Qiao…·Arul M. Chinnaiyan
This study identifies a therapeutic vulnerability in POU2F-POU2AF-driven cancers by showing that targeting the mSWI/SNF complex with a PROTAC degrader reduces tumor growth in preclinical models.
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