Biodistribution of mRNA vaccines in rats: Enrichment in injection site and lymph tissues and rapid clearance without tissue persistence
Susan M.G. Goody, Christopher Rowbottom, Yun Liu, Nancy Chen
Three mRNA-LNP products sharing one lipid matrix show rat intramuscular biodistribution (injection site, lymph nodes, spleen) and rapid clearance, with no Spike accumulation after repeat dosing.
Molecular Therapy — Nucleic Acids · May 6, 2026Peer-reviewedPharmacology & Toxicology✦ In-depth digest