Author

Neethu Michael

University of California, Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2

Frequent Co-Authors

Emily MiyoshiiD· 4 shared Vivek SwarupiD· 4 shared Alice Lau· 2 shared Andrea M. Reyes-OrtiziD· 2 shared Jie WuiD· 2 shared Leslie Michels ThompsoniD· 2 shared Nicolette R. GelleriD· 2 shared Ricardo MiramontesiD· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersNeuroscience

Emily MiyoshiORCID

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Author profile →

4 papers

Recent·Most cited

Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's Disease

Emily Miyoshi, Samuel Morabito, Caden M. Henningfield, Sudeshna Das, Negin Rahimzadeh, Sepideh Kiani Shabestari, Neethu Michael, Nora Emerson, Fairlie Reese, Zechuan Shi, Zhenkun Cao, Shushrruth Sai Srinivasan, Vanessa M. Scarfone, Miguel A. Arreola, Jackie Lu, , Vivek Swarup

This study uses spatial transcriptomics and single-nucleus RNA-seq to compare genetic and sporadic Alzheimer's Disease, finding similar spatial and cell-type specific changes between sporadic AD and AD in Down Syndrome.

Nature Genetics · Nov 22, 2024Peer-reviewedNeuroscience

Integrated transcriptome analysis of Huntingtons disease iPSC-derived and mouse astrocytes implicates dysregulated synaptogenesis, actin, and astrocyte maturation

Andrea M. Reyes-Ortiz, Edsel M. Abud, Mara S. Burns, Jie Wu, Sarah J. Hernandez, Nicolette R. Geller, Keona Q. Wang, Corey J. Schulz, Ricardo Miramontes, Alice Lau, Neethu Michael, Emily Miyoshi, Mathew M. Blurton-Jones, David Van Vactor, John C. Reidling, , Leslie Michels Thompson

This study compares HD astrocytes from human iPSCs and mouse models, identifying dysregulated synaptogenesis, actin signaling, and maturation, with unique human findings and potential therapeutic targets.

bioRxiv · Jul 28, 2022 · PreprintNeuroscience

Single nuclei RNAseq analysis of HD mouse models and human brain reveals impaired oligodendrocyte maturation and potential role for thiamine metabolism

Ryan G. Lim, Osama Al‐Dalahmah, Jie Wu, Maxwell P. Gold, Jack C. Reidling, Guomei Tang, Miriam Adam, David K. Dansu, Hye-Jin Park, Patrizia Casaccia, Ricardo Miramontes, Andrea M. Reyes-Ortiz, Alice Lau, Fatima Khan, Fahad Paryani, , Leslie Michels Thompson

This study uses snRNAseq to analyze HD mouse models and human brain tissue, identifying impaired oligodendrocyte maturation and a potential role for thiamine metabolism in disease pathology.

bioRxiv · Jun 27, 2022 · PreprintNeuroscience

Integrative genomics approach identifies conserved transcriptomic networks in Alzheimer’s disease

Samuel Morabito, Emily Miyoshi, Neethu Michael, Vivek Swarup

This study identifies conserved transcriptomic networks in Alzheimer’s disease by integrating multi-omics data across multiple cohorts and cell types.

Human Molecular Genetics · Aug 12, 2020Peer-reviewedNeuroscience