NeurosciencebioRxivPreprint
Integrated transcriptome analysis of Huntingtons disease iPSC-derived and mouse astrocytes implicates dysregulated synaptogenesis, actin, and astrocyte maturation
Andrea M. Reyes-Ortiz, Edsel M. Abud, Mara S. Burns…·Leslie Michels Thompson
This study compares HD astrocytes from human iPSCs and mouse models, identifying dysregulated synaptogenesis, actin signaling, and maturation, with unique human findings and potential therapeutic targets.