Author

Nicholas Lyons

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Aravind SubramanianiD· 2 shared Ajay PillaiiD· 1 shared Albert Lee· 1 shared Alexandra B. London· 1 shared Avi Ma’ayaniD· 1 shared Brook T. Wassie· 1 shared Caitlin E. MillsiD· 1 shared Cemal ErdemiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Aravind SubramanianORCID

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2 papers

Recent·Most cited

An induced pluripotent stem cell-based chemical genetic approach for studying spinal muscular atrophy

Richard M. Giadone, Kristina M. Holton, Xiaoyu Hu, Ted E. Natoli, Sabrina Ghosh, Stanley Gill, Nicholas Lyons, Aravind Subramanian, Lee L. Rubin

The paper uses a chemical genetic approach with induced pluripotent stem cells to screen for compounds affecting SMA neuronal gene expression, generating a queryable dataset of transcriptional profiles.

Frontiers in Neuroscience · Feb 4, 2026Peer-reviewedNeuroscience

A LINCS microenvironment perturbation resource for integrative assessment of ligand-mediated molecular and phenotypic responses

Sean M. Gross, Mark A. Dane, Rebecca Lee Smith, Kaylyn L. Devlin, Ian C. McLean, Daniel S. Derrick, Caitlin E. Mills, Kartik Subramanian, Alexandra B. London, Denis Torre, John Erol Evangelista, Daniel J. B. Clarke, Zhuorui Xie, Cemal Erdem, Nicholas Lyons, , Laura M. Heiser

The paper presents a LINCS Microenvironment perturbation dataset cataloging transcriptional, proteomic, epigenomic, and phenotypic responses of MCF10A cells to six ligands, enabling integrative analysis of molecular and phenotypic changes.

Communications Biology · Oct 7, 2022Peer-reviewedSystems Biology