Kristina M. Holton

The paper identifies signaling pathways that drive the differentiation of brain endothelial cells from hiPSCs in vitro.

The paper shows that depleting the gut microbiome in aged mice rejuvenates the brain by improving vascular density, myelination, neurogenesis, and reducing inflammation.

The paper uses a chemical genetic approach with induced pluripotent stem cells to screen for compounds affecting SMA neuronal gene expression, generating a queryable dataset of transcriptional profiles.

The paper uses ER stressors in ALS patient-derived motor neurons to identify druggable targets that protect against degeneration.

The paper combines epidemiological pesticide exposure data with iPSC-derived dopaminergic neuron screening to identify and classify pesticides linked to Parkinson's disease.

The paper develops an automated high-content synaptic phenotyping platform in human neurons and astrocytes, identifying BET inhibitors as key regulators of synapse assembly.

This study uses single-cell transcriptomics to show that heterochronic parabiosis alters aging signatures in multiple brain cell types, with endothelial cells showing significant transcriptional changes.

This study identifies Creb5 as a transcription factor required for TGF-β and EGFR signaling to induce Prg4 expression in superficial zone articular chondrocytes.

The paper characterizes S1PR1-regulated transcriptomes in aortic endothelial cells, revealing distinct subtypes and signaling mechanisms in arterial and lymphatic endothelium.

The paper identifies distinct functional recovery trajectories in first episode psychosis patients using data-driven methods and explores associated risk factors.