Ian C. McLean

This study identifies HIF1A as a key mediator of OSM-induced collective epithelial migration, linking cytokine signaling to metabolic and immune pathways in breast cancer.

The paper develops MMIST, a computational approach linking live-cell morphodynamics to gene expression changes during cell state transitions.

This study identifies immune mimicry in breast cancer cells, where neoplastic cells express leukocyte receptors, enhancing tumor aggressiveness and therapy resistance.

The paper introduces a framework for mathematical modeling of multicellular systems using interpretable cell behavior rules derived from biological knowledge and multi-omics data.

This study investigates how combinations of EGF, OSM, and TGFB cytokines synergistically drive cell motility through CXCR2 chemotaxis and CREB activation in MCF10A cells.

The paper presents a LINCS Microenvironment perturbation dataset cataloging transcriptional, proteomic, epigenomic, and phenotypic responses of MCF10A cells to six ligands, enabling integrative analysis of molecular and phenotypic changes.