Author

Nicole E. McCormick

Dalhousie University

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Bioinformatics· 1

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Organism:bacteria (other)· 1 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:metagenomics· 1 Approach:statistical model· 1

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A. ComeauiD· 1 shared Akhilesh S. DhananiiD· 1 shared Casey M. A. JonesiD· 1 shared Dhwani DesaiiD· 1 shared Gavin M. DouglasiD· 1 shared Jacob T. NearingiD· 1 shared Jocelyn MacDonald· 1 shared Molly G. HayesiD· 1 shared

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1 paper

Recent·Most cited

BioinformaticsNature CommunicationsPeer-reviewedJan 17, 2022

✦ In-depth digest

Microbiome differential abundance methods produce disturbingly different results across 38 datasets

Jacob T. Nearing, Gavin M. Douglas, Molly G. Hayes…·Morgan G. I. Langille

In 38 two-group 16S rRNA datasets, 14 differential abundance tools disagreed sharply; ALDEx2 and ANCOM-II were conservative and consistent, while edgeR and LEfSe inflated false positives.

1,005 citationstop 1%

bacteria (other)human

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