MicrobiologybioRxivPreprint
HIV-1 promotes loss of CD4+ T cell stemness and enrichment of effector-like states via Vpr-mediated TCF7 degradation
Johanna Leyens, Anthea Darius, Carlos Alberto Vanegas-Torres…·Michael Schindler
This study identifies Vpr-mediated TCF7 degradation as a mechanism by which HIV-1 reduces CD4+ T cell stemness and promotes effector-like states.
DOI 10.64898/2026.07.31.741970