Nils Eikmeier

Scanning DIA on the ZenoTOF 8600 system records a precursor dimension for every fragment at tenfold higher ion flux

The paper introduces the ZenoTOF 8600 system, which enhances proteomics by increasing ion flux and improving precursor identification and quantification in DIA mode.

In situ polymerized monolith tips for reproducible, format-flexible proteomic sample preparation applied to biofluids

The paper introduces pSPEC, a reproducible proteomic sample preparation method for biofluids that increases protein identification by ~20% compared to in-solution plasma.

In the same cell, the proteome defines cellular state and the transcriptome marks transitions

The paper quantifies proteins and transcripts in the same cell, finding that the proteome defines stable cell states while the transcriptome reflects transitions.

Regulated conformational transitions in seipin define a functional ER–lipid droplet interface

This study shows seipin undergoes conformational changes at the ER-LD interface, enabling lipid droplet growth and regulated lipid storage.

Multimodal phenotyping defines variant-to-function maps for RBM20 in dilated cardiomyopathy

The paper develops a deep mutational scanning framework to map variants to molecular functions in RBM20, identifying functional hotspots and therapeutic strategies for dilated cardiomyopathy.