Jennifer L. Sapia

The paper shows TWD1 enhances IAA transport by isomerizing the E1007-P1008 bond in ABCB1, while not affecting BL transport, revealing a mechanism that prioritizes auxin over brassinosteroid transport.

This study shows seipin undergoes conformational changes at the ER-LD interface, enabling lipid droplet growth and regulated lipid storage.

This study investigates how substrate-dependent oligomerization affects DGAT1 activity and subcellular localization through molecular dynamics, biochemical reconstitutions, and live-cell fluorescence microscopy.

This study shows lipid droplets are the site of VLCFA activation by Fat1, with Fat1 targeting LDs via an amphipathic helix and using a hydrophobic cavity to access substrates.

This study shows that PPARγ controls adipose tissue expansion by regulating LPCAT3, which affects membrane lipid composition and triglyceride storage, linking dietary n-6 PUFAs to energy balance.

This study identifies two regulatory elements in ABHD17 enzymes that modulate their activity through S-acylation and membrane interactions.

This study determines the structure of the yeast ceramide synthase complex using cryo-EM, revealing its active state and inhibition mechanism by fumonisin B1.