Stefano Vanni

The paper identifies PfTUPA, a novel lipid transfer protein in Plasmodium falciparum essential for lipid recycling from the digestive vacuole.

The paper identifies how amphipathic helices bind to the inner nuclear membrane by sensing lipid packing defects rather than electrostatics, showing the INM's loose packing under basal conditions.

This paper evaluates AlphaFold3's performance across diverse structural biology tasks, finding uneven accuracy and strong dependence on training data.

This study identifies Brl1 and Brr6 as conserved fusogens mediating membrane fusion during NPC assembly in eukaryotes.

This study shows seipin undergoes conformational changes at the ER-LD interface, enabling lipid droplet growth and regulated lipid storage.

This study investigates how substrate-dependent oligomerization affects DGAT1 activity and subcellular localization through molecular dynamics, biochemical reconstitutions, and live-cell fluorescence microscopy.

This study shows lipid droplets are the site of VLCFA activation by Fat1, with Fat1 targeting LDs via an amphipathic helix and using a hydrophobic cavity to access substrates.

This study uses molecular dynamics simulations to reveal the mechanism of lipid transport by BLTPs, showing membrane destabilization is critical for lipid desorption.

The paper uses cryo-EM to study the VPS13A-XKR1 complex, revealing how it facilitates lipid transfer between membranes and how this process is enhanced by membrane properties.

This study identifies an ancient membrane fission mechanism in Asgard archaea, showing ESCRT-III's role in cell compartmentalization predates eukaryogenesis.

This study identifies CLCC1 as a Torsin1A binding partner essential for nuclear envelope membrane fusion during NPC biogenesis, showing its therapeutic potential for DYT1 dystonia.

This study shows that PPARγ controls adipose tissue expansion by regulating LPCAT3, which affects membrane lipid composition and triglyceride storage, linking dietary n-6 PUFAs to energy balance.

The paper identifies LPCAT3 as a cold-regulated enzyme that generates AA-PE in BAT mitochondria, enhancing ETC efficiency and thermogenesis.

The paper identifies TMEM170 family proteins as lipid scramblases that physically interact with BLTP1/Csf1, revealing a new mechanism for lipid transport between organelles.

This study identifies Pex30's role in maintaining ER lipid homeostasis through membrane contact sites with peroxisomes and vacuoles in budding yeast.

This study identifies two regulatory elements in ABHD17 enzymes that modulate their activity through S-acylation and membrane interactions.

This study uses molecular dynamics simulations to show that RNA order determines its interaction with zwitterionic lipid bilayers, explaining experimental observations about RNA affinity for gel-phase membranes.

This study determines the structure of the yeast ceramide synthase complex using cryo-EM, revealing its active state and inhibition mechanism by fumonisin B1.

This study determines the cryo-EM structure of native yeast eisosomes, revealing lipid organization and dynamic stretching mechanisms in membrane microdomains.

This study uses unbiased MD simulations to identify lipid binding pockets in LTPs, providing insights into lipid entry pathways for bridge-like LTPs.

The paper shows lipid scrambling is a general feature of protein insertases, suggesting they may function as scramblases in membrane dynamics.

This paper improves the SPICA force field to better simulate proteins, including IDPs and peripheral proteins, by introducing secondary structure-dependent nonbonded parameters and re-optimizing interactions.

The paper shows DLC3/Cv-c is essential for testis development in humans and Drosophila, with the StART domain mediating function independent of the GAP domain.

The paper investigates how membrane tension, lipid shape, and curvature interact to influence lipid packing defects and membrane deformation through ALPS binding and conical lipid effects.