S-nitrosylation of protein kinase A is required for its activation by GPCRs
Sherif M. F. M. Bahriz, Zhenduo Zhu, Bing Xu, Jian Wu, Ning Cao, Chaoqun Zhu, Wen Pan, Caeser Tawfeeg, Zhuer Zeng, Johannes W. Hell, Qingtong Wang, Richard T. Premont, Ying Wang, Jonathan S. Stamler, Susan Serota Taylor, Yang K. Xiang
This study shows that S-nitrosylation of PKA regulatory subunits by SCAN is required for GPCR-induced PKA activation in heart, brain, and fat tissues.
bioRxiv · May 31, 2026 · PreprintPhysiology