Ying Wang

A network of bZIP transcription factors and inhibitors enforces differentially proliferative and cytotoxic states in T cells

This study identifies bZIP transcription factors and inhibitors that influence T-cell proliferation and cytotoxicity under exhaustion conditions.

Specification of bone marrow sinusoids requires TIE2-mediated positive feedback involving COUPTFII and VEGFR3

This study identifies TIE2-mediated positive feedback involving COUPTFII and VEGFR3 as essential for bone marrow sinusoid specification.

An efficient system for production of highly purified inhibins using mammalian cell expression and tandem affinity purification

This paper develops a method to produce highly purified inhibins using mammalian cell expression and tandem affinity purification, achieving high yields and purity with minimal activin contamination.

Cell junction disruption drives translocation of gasdermin A and gasdermin B from cytoskeleton to plasma membrane during acantholysis

The paper shows that cell junction disruption in keratinocytes leads to translocation of GSDMA and GSDMB from cytoskeleton to plasma membrane without cleavage, but without cytokine release.

An interoperable research agent network for scientific discovery

This paper introduces GUIA, an interoperable research-agent network that enables collaboration between scientific agents across domains, demonstrating its utility in therapeutic target discovery, drug discovery, and spatial proteomics analysis.

Cytokines driven by caspase-1 and RIPK3 are antagonistic

The paper shows that cytokines from caspase-1 and RIPK3 pathways antagonize each other during infection, determining immune response outcomes rather than cell death pathways alone.

BubR1 TPR domain supports mitotic checkpoint by promoting MCC formation and MCC-APC/C interaction

This study identifies the BubR1 TPR domain's role in SAC signaling by promoting MCC formation and MCC-APC/C interaction through structural and functional analyses.

S-nitrosylation of protein kinase A is required for its activation by GPCRs

This study shows that S-nitrosylation of PKA regulatory subunits by SCAN is required for GPCR-induced PKA activation in heart, brain, and fat tissues.

A cross-tissue POSTN+ fibroblast atlas links periodontal, tumor, and fibrotic stromal niches

The paper constructs a cross-tissue fibroblast atlas to identify a conserved POSTN+ program across multiple disease contexts and validates its robustness through multiple analyses.

GIRAF 1.0: A unified global framework to anticipate plant pest invasions

GIRAF 1.0 assesses global pest invasion risks by integrating host data, environmental suitability, trade networks, and policies, revealing high vulnerability in many countries.

Minimal biophysical rules are sufficient for the emergence of computational intelligence at the neuronal scale

The paper shows that minimal biophysical constraints can generate a connectome matching a mouse V1 microcircuit and enable a neural network to perform auditory classification.

MEF2A is a negative regulator of β-Cell maturation and function

This study identifies MEF2A as a negative regulator of beta cell maturation and function, showing that its overexpression impairs beta cell identity and insulin secretion under ER stress.

MAPK signaling modulates the partition of DCP1 between P-bodies and stress granules in plant cells

The paper investigates how MAPK signaling affects DCP1 localization between P-bodies and stress granules in plant cells, showing phosphorylation shifts DCP1 from P-bodies to stress granules.

1,3- and 1,4-linked Polysaccharides Uptake in Intestinal Cells Relies on Clathrin/Dynamin 1/Rab5-dependent Endocytosis

Orally administered β-1,3- and α-1,4-linked polysaccharides cross intestinal epithelium into rodent plasma and liver as macromolecules via clathrin-, dynamin 1-, and Rab5-dependent endocytosis mediated by EGFR, Dectin-1, and BMPRIA.

Covalent Leader Peptide Probes Enable Proteome-Level Mapping of RiPP Enzymes beyond Biosynthetic Gene Clusters

This study develops covalent leader peptide probes to identify RiPP enzymes outside biosynthetic gene clusters, revealing cross-cluster enzymatic interactions.

The novel variant IBDV induces inflammatory responses via VP3-mediated pyroptosis by directly targeting Caspase-9

This paper identifies that the novel variant IBDV induces inflammatory responses through VP3-mediated pyroptosis by directly targeting Caspase-9, with Serine 33 as a critical amino acid for this interaction.

Lithium Chloride Inhibits Iron Dysregulation and Ferroptosis in Induced Pluripotent Stem Cells with ApoE4/E4 from a sporadic Alzheimer's disease patient

This study shows lithium chloride reduces iron dysregulation and ferroptosis in ApoE4/E4 iPSCs from a sporadic Alzheimer's patient, improving cell viability and mitochondrial function.

Seasonal dynamics of mixotrophic phytoplankton in a freshwater habitat revealed by single-cell sorting

This study uses single-cell sorting to identify and track seasonal changes in mixotrophic phytoplankton in a freshwater habitat, revealing their ecological roles and diversity.

Intranasal Delivery of Lithium Salt Suppresses Inflammatory Pyroptosis in the brain and Ameliorates Memory Loss and Depression-like Behavior in 5XFAD mice

This study shows that intranasal lithium salt delivery in RFV reduces brain inflammation and pyroptosis, improves memory and depression-like behaviors in 5XFAD mice, with minimal side effects.

Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder

This study identifies 30 genome-wide significant loci for obsessive-compulsive disorder (OCD) using a large GWAS, linking risk to specific brain cell types and shared genetic risk with other psychiatric and non-psychiatric traits.

Intranasal dantrolene nanoparticles inhibit inflammatory pyroptosis in 5XFAD mice brains

This study shows that intranasal dantrolene nanoparticles reduce pyroptosis and inflammation in 5XFAD mice brains without affecting organ function or body weight.

Genome assembly and genomic architecture of a prominent cold-resistant rapeseed germplasm

The paper assembles a high-quality genome of a cold-tolerant rapeseed cultivar and identifies genomic features associated with cold resistance.

Identifying a developmental transition in honey bees using gene expression data

The paper develops a statistical method to identify bistability near developmental transitions from gene expression data and applies it to honey bees.

Fibroblast activation during decidualization: Embryo-derived TNFα induction of PGI2-PPARδ-ACTIVIN A pathway through luminal epithelium

This study identifies a pathway by which embryo-derived TNFα induces fibroblast activation and decidualization through the arachidonic acid-PGI2-PPARδ-ACTIVIN A axis in mouse and human endometrium.

A shift in the mechanisms controlling hippocampal engram formation during brain maturation

This study shows that the maturation of hippocampal inhibitory interneurons by extracellular matrix is necessary for the development of precise episodic-like memories in mice.

NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice

This study shows that NSC-derived exosomes improve the therapeutic effects of NSC transplantation in mice with cerebral ischemia by reducing inflammation, oxidative stress, and promoting differentiation and tissue recovery.

SAINT: automatic taxonomy embedding and categorization by Siamese triplet network

SAINT is an alignment-free sequence comparison method using a Siamese triplet network for efficient and accurate taxonomy embedding and categorization.

Capsule network for protein ubiquitination site prediction

The paper introduces a deep learning model called Caps-Ubi for predicting ubiquitination sites across species, achieving high accuracy and outperforming existing predictors.

Employing single-stranded DNA donors for the high-throughput production of conditional knockout alleles in mice

This study tests CRISPR/Cas9 with ssODNs and lssODNs for generating conditional knockout alleles in mice, finding higher efficiency with lssODNs.

Scalable Production of Human Erythrocytes from Induced Pluripotent Stem Cells

This paper describes a scalable, xeno-free method to produce human erythrocytes from hiPSCs, achieving high yields and purity.