Medulloblastoma Forms Symbiotic Metabolic Partnerships with Macrophages to Establish Leptomeningeal Metastases
Vernon Fong, Michelle Ly, Anders Wilder Erickson, Namal Abeysundara, Liam D. Hendrikse, Randy Van Ommeren, Polina Balin, Jigyansa Mishra, Bryn G. Livingston, Patryk Skowron, Olga Sirbu, Ncedile Mankahla, Jiao Zhang, Cory M. Richman, Raul Suarez, , Xiaochong Wu
This study identifies metabolic partnerships between medulloblastoma and macrophages that drive leptomeningeal metastases and suggests targeting the CXCL12-SCARB1-cholesterol axis as a therapeutic strategy.
bioRxiv · Aug 9, 2026 · PreprintCancer Biology