Cancer BiologybioRxivPreprint
Profilin 1 maintains cell cycle fidelity to prevent unscheduled genome doubling and polyploidy in cancer
Federica Scotto di Carlo, Sharon Russo, Simon Gemble…·Fernando Gianfrancesco
This study identifies Profilin 1 as a safeguard against genome doubling and polyploidy in cancer by showing its role in maintaining cell cycle fidelity and preventing therapeutic resistance.
DOI 10.64898/2026.05.12.724607