ImmunologybioRxivPreprint
Hypoxia-mediated fine-tuning of the TLR7/9-triggered human PDC-derived IFN-α response is mediated by combined cellular and soluble IFN-regulators
Alexander Lenkewitz, Ibtissem Ben Brahim, Felix Herrmann…·Isabelle Bekeredjian‐Ding
The paper shows hypoxia reduces IFN-α secretion from PDCs but preserves their production capacity, mediated by soluble factors and cell contact mechanisms.
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